Increasing Botox Effect And Duration With Zinc

Written by A.H. Nezami, MD.,  director and founder of Jacksonville Cosmetic Surgery Center.

Botox Cosmetic injection has become more popular, with more patients taking advantage of this easy way to reduce wrinkles on the forehead, crow’s feet and between the eyebrows or to reduce sweating under the armpit. Botox has thousands of other non-cosmetic uses as well.   We previously wrote on our blog: Curious about Botox? Jacksonville’s Dr. A.H. Nezami Explains All You Need to Know. and Botox Injections: How to benefit the most and have the best result. We encourage readers to refer to those blogs for additional information.
The effect of Botox cosmetic injection appears quickly within 3 to 7 days. Repeated treatment is needed to maintain the benefits of Botox cosmetic, typically within 3 to 4 months.
Botox needs zinc to work properly. Knowing this fact, Oculoplastic surgeon, Dr. Charles Soparkar and his team in a pilot clinical study compared the effectiveness of Botulinum Toxin injections (Botox, Myobloc, or Dysport) with either zinc citrate 50 mg plus phytase 3,000 PU, zinc gluconate 10 mg, or placebo supplementation in individuals being treated for blepharospasm, hemifacial spasm, and cosmetic wrinkles. “Surprisingly, the results showed that in over ninety percent of the patients studied, the zinc/phytase combination resulted in a remarkable improved responsiveness to treatment of blepharospasm using the same amount of Botulinum toxin as previously used,” said Soparkar, M.D. “The toxins seemed to have greater effect and last longer. Potentially, this could mean using less toxin, offering patients financial savings, greater safety, and more consistent results.” This study was recently published: Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatology 2012 Apr 1; 11(4):507-12.
ZYTAZE™ is a prescription nutritional supplement manufactured by OCuSOFT.    Each capsule contains Zinc Citrate 25 mg and Phytase 1500 mg.  ”Two capsules daily for four days prior to and on the day of receiving botulinum toxin injections.  Each prescription package contains 10 capsules. ZYTAZE™ may be taken during meals or snacks, but avoid taking ZYTAZE™ within two hours of other medications and / or supplements.    ZYTAZE™ is a medical food and is intended to be used under the supervision of a physician.” For answers to frequently asked questions and more information about the product, please visit
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